Two former players came back to haunt the Poachers as their revival came to an end.
Nick Jackson and Josh Ford were both on the mark in the second half as a strong-looking Holbeach side ran out 3-1 winners.
Earlier, Jake Clitheroe had given the visitors the lead after just eight minutes.
Curtis Revell scored his first goal for Boston to pull one back with ten minutes left.
Town: J Lambley, L Lambley, D Wood, S Ashton, M Wood, Ford, Bayliss, Parker, Beck, Wightwick, Smith
Photo (c) BUFC